In 2020, the COVID-19 pandemic gripped the world, and clinicians scrambled to find effective treatments for their patients. Through unprecedented rates of research and collaboration across disciplines, several therapies were demonstrated to show promise, while others fell short. In this piece, we argue clinical trials can—and, indeed, must—be done during a pandemic to identify safe and effective therapeutics and that these trials must be completed free of political pressures. For optimal treatments, we ought to prepare clinical trials before—not during—public health emergencies.

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